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BIOMEDICAL APPLICATION OF FREE-STANDING Ti3C2TX MXENE FILMS

Kateryna Diedkova1, 2 *, Volodymyr Deineka3, 1, Yevheniia Husak1, 4, Ivan Baginskyi5, Serhii Dukhnovskiy5, Veronika Zahorodna5, Sergiy Kyrylenko1, Oleksiy Gogotsi5, Maksym Pogorielov1, 3

1) Sumy State University, Sumy (Ukraine)

2) Institute of Atomic Physics and Spectroscopy, University of Latvia (Latvia)

3) University of Latvia, Riga (Latvia)

4) Silesian University of Technology, Faculty of Chemistry (Poland)

5) Materials Research Center, Y-Carbon Ltd, Kyiv (Ukraine)

* katefei93@gmail.com

A new 2D material, MXene, appeared on the research scene recently and has generated considerable interest among scientists from engineers and physicists to biologists and physicians. Among these materials, Ti3C2Tx MXene has garnered significant attention due to its unique properties, including high electrical conductivity, excellent mechanical strength, and biocompatibility. Free-standing Ti3C2Tx MXene films, in particular, have shown great potential in various biomedical applications, biosensors, biological imaging, and therapeutic diagnosis. The question of how free-standing MXene film interacts with biological systems is becoming increasingly important due to the new nanomaterial's extensive application in biomedical advancements. The aim of our research was to evaluate the biological and structural properties of Ti3C2Tx MXene film.

Free-standing Ti3C2Tx MXene-film was prepared by Materials Research Center (Kyiv, Ukraine). The surface morphology of MXene film was characterized by scanning electron microscopy (SEM, Phenom ProX, Phenom-World BV, the Netherlands). Static and dynamic contact angles MXene-films were used to evaluate the hydrophobicity/hydrophilicity of a solid surface by video-based optical contact angle measuring equipment OCA 15 EC, Series GM-10-473 V-5.0 (Data Physics, Filderstadt, Germany). Cytotoxicity and proliferation effects of the material were evaluated using human keratinocytes (HaCaT).

Our results demonstrate that the free-standing MXene film has a multilayer composite structure with a rough, disordered surface. Biological investigations have shown that the film is non-toxic, promotes cell proliferation and provides a significant active surface for interaction with keratinocytes. We noticed that after 6 days of incubation in a cell culture medium, the film lost its flexibility and original shape.

To summarize, the free-standing MXene films in combination with polymer scaffolds have a promising future in biomedical applications. 


Keywords:

MXene film, biological properties, tissue engineering, biocompatibility, biomedicine

Acknowledgements:

This research was funded by FP-21711-ZF-N-109 - Tailored Molecular Transport in Low-Dimensional Hybrid Materials from 1D Nanocrystals and 2D Nanosheets.

Track: Nanobiomedical Research & Applications (NRA)
Presentation type: Poster Presentation
Status: Accepted for presentation